Pharmacokinetics — Compartmental Models & Drug Dosing

Chemistry

Advanced 120 minutes 2 lessons

PhD-level pharmacokinetics: one- and two-compartment models for intravenous bolus, infusion, and oral dosing; derived PK parameters (volume of distribution, clearance, bioavailability, half-life, AUC); multiple-dose accumulation and steady-state concentration; population PK with nonlinear mixed-effects models and the implications for individualised dosing.

Learning Objectives

Derive and solve the one-compartment IV bolus model ODE and compute all primary PK parameters
Apply the superposition principle to predict plasma concentration profiles after multiple oral doses
Set up the two-compartment model differential equations and identify macro rate constants α and β
Interpret population PK model outputs (fixed effects, random effects, shrinkage) for dose individualisation
Apply Bayesian estimation with limited sampling to predict patient-specific PK parameters