Pharmacodynamics — Receptor Theory, Dose-Response & PK/PD Integration

Chemistry

Advanced 120 minutes 2 lessons

PhD-level pharmacodynamics: receptor occupancy theory, Hill–Emax dose-response model and its derivation from the law of mass action, Schild analysis for competitive antagonists, time-delayed PK/PD models with effect-compartment linking, tolerance and sensitisation, and applications to therapeutic window design and clinical trial endpoint selection.

Learning Objectives

Derive the Hill–Emax equation from the law of mass action and receptor occupancy theory
Apply Schild regression to quantify competitive antagonism and compute the pA2 value
Distinguish direct-effect PK/PD models from effect-compartment (biophase) models and indirect-response models
Compute the effect-site equilibration half-life (t½keo) and predict the temporal dissociation between PK and PD
Design a dosing regimen to maintain drug effect within the therapeutic window throughout the dosing interval